(S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid → 1-[4-[2-(1H-Imidazol-1-yl)-ethoxy]-4-pyridin-3-yl-piperidin-1-yl]-2-[[(2S)-1-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-piperidin-2-yl]-methoxy]-ethanone

Participants

Role	Name	HCID	Charge
Reactant	(S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid	HCID 57819715	—
Reactant	tert-butyl 4-(2-(1H-imidazol-1-yl)ethoxy)-4-(pyridin-3-yl)piperidine-1-carboxylate	HCID 57916243	—
Product	1-[4-[2-(1H-Imidazol-1-yl)-ethoxy]-4-pyridin-3-yl-piperidin-1-yl]-2-[[(2S)-1-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-piperidin-2-yl]-methoxy]-ethanone	HCID 44465887	60%

Reaction Steps

The desired target compound was synthesized under reaction conditions analogously to the process described for Example 61 (see below) from (S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid [acid D] and tert-butyl 4-(2-(1H-imidazol-1-yl)ethoxy)-4-(pyridin-3-yl)piperidine-1-carboxylate [amine F]. Yield: 60%. MS, Rt=2.7 min, m/z=626.4 [MH]+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08318769B2
Source dataset	uspto-grants-2012_11
ORD ID	ord-336faf86e07f4ba588ffe61d2714cf99
Source note	uspto-grants-2012_11