Hydrochloric Acid → HCID 178508795, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of tert-butyl 4-(2-(benzyloxycarbonyl)-3-(3,5-diamino-6-chloropyrazine-2-carbonyl)guanidino)piperidine-1-carboxylate (Step 1) (6.3 g, 11.5 mmol) in dioxane (250 mL) and MeOH (small volume) is treated with 4 M HCl in dioxane (40 mL) and left to stir overnight at 40° C. The resulting suspension is filtered and the solid is partitioned between water (800 mL) and EtOAc (800 mL). 1 M NaOH is added to adjust the pH to pH 8 and the organic portion is separated, dried (MgSO4) and concentrated in vacuo to afford the title compound. [M+H]+ 447

Provenance & Evidence