Terephthaloyl chloride → HCID 66917476, compound

Participants

Reaction Steps

A solution of terephthaloyl chloride (1.02 g, 5.0 mmol) in DMF (10 mL) under an inert atmosphere of argon is treated dropwise with a solution of 4-(N-Boc-amino)piperidine (2.00 g, 10.0 mmol) over 20 minutes. The reaction mixture is allowed to stir at room temperature for 40 minutes and then TEA (2.09 mL, 15.0 mmol) is added dropwise. A white suspension forms and stirring continues for 2 hours. The resulting mixture is washed with saturated NaHCO3 solution (50 mL) and water (100 mL). The resulting mixture is filtered under vacuum using phase separating paper to afford a white solid. The solid is dried under vacuum at 45° C. to yield the required product. [M+H]+ 531

Provenance & Evidence