HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Bromo-6-(hydroxymethyl)nicotinaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | {5-[Bis(methyloxy)methyl]-3-bromo-2-pyridinyl}methanol | HCID 67428521 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Bromo-6-(hydroxymethyl)nicotinaldehyde | HCID 86664885 | 87% |
Reaction Steps
A mixture of {5-[bis(methyloxy)methyl]-3-bromo-2-pyridinyl}methanol (98 mg, 0.374 mmol) and 1N HCl (3.26 mL, 3.26 mmol) in DCM (5 mL) was stirred overnight. DCM and 1M NaOH solution were added. Extraction, drying (Na2SO4), and filtration afforded 5-bromo-6-(hydroxymethyl)-3-pyridinecarbaldehyde (70 mg, 87%) as a brown oil pure enough to be used in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318940B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-d4a25755496243068795a2cba435d0c2 |
| Source note | uspto-grants-2012_11 |