HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → HCID 86611641, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 5,6-Dimethoxy-2-(pyridin-4-ylmethyl)indan-1-one | HCID 10085230 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 86611641 | HCID 86611641 | 108.8% |
Reaction Steps
0.60 g of 2,3-dihydro-5,6-dimethoxy-2-((pyridin-4-yl)methyl)inden-1-one, and 0.36 g p-toluenesulfonic acid salt were added to 30 mL of anhydrous methanol. 60 milligrams of PtO2 were added. The reaction mixture was stirred at room temperature, with H2 being added at 1 atmosphere for 6 hours. Solids were filtered off. The filtrate was concentrated and dried in vacuo to afford 1.05 g of foam with 100% yield. Liquid chromatography analysis of this product showed 97% purity.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318942B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-8cf546c807fe471b9c7c11da39cf39ae |
| Source note | uspto-grants-2012_11 |