HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Formylbenzoic acid → 4-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]benzoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Formylbenzoic acid | HCID 12088 | — |
| Reactant | 8-Cyclohexyl-2,8-diazaspiro[4.5]decane | HCID 67500672 | — |
| Product | 4-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]benzoic Acid | HCID 68956097 | 169.2% |
Reaction Steps
Except for using 4-formylbenzoic acid (112 mg) in place of 4-(diethoxymethyl)benzaldehyde and using 8-cyclohexyl-2,8-diazaspiro[4.5]decane (170 mg) in place of 8-isobutyl-2,8-diazaspiro[4.5]decane, the same operation as in Example 26 was performed to obtain the title compound (450 mg) having the following physical properties.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318931B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-575b4f9abd1e499ea60ad0816c4be1ea |
| Source note | uspto-grants-2012_11 |