Lawesson's reagent → HCID 59331536, compound

Participants

Reaction Conditions

Reaction Steps

To a solution (10 mL) of 5-{2-cyclopentyl-1-[4-(methylsulfonyl)phenyl]ethyl}-3-methyl-1H-pyrrole-2-carboxamide (135 mg) in tetrahydrofuran was added Lawesson's reagent (156 mg), and the mixture was stirred for 3 hr at 55° C. After cooling to room temperature, the reaction mixture was concentrated, the residue was subjected to silica gel column chromatography, and the title compound (120 mg, yield 86%) was m obtained as yellow amorphous crystals from a fraction eluted with ethyl acetate-hexane (1:1, volume ratio). MS: 391 (MH+).

Provenance & Evidence