Hydrochloric Acid → HCID 59331463, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 3-cyclopentyl-2-[4-(cyclopropylsulfonyl)phenyl]propanoate (1.95 g) in a mixed solvent of tetrahydrofuran (40 mL) and methanol (20 mL) was added 2N aqueous sodium hydroxide solution (10 mL), and the mixture was stirred at 50° C. for 3 hr. The reaction mixture was acidified with 1N hydrochloric acid, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from hexane-diethyl ether to give the title compound (1.67 g, 89%) as colorless crystals. MS: 323 (MH+).

Provenance & Evidence