Hydrochloric Acid → HCID 178478329, compound

Participants

Reaction Steps

To 5% aqueous sodium chlorite solution (180 mL) was added sodium hydroxide (737 mg) and completely dissolved. To the reaction solution was added 2-(5-iodo-1H-imidazol-2-yl)pyridine (5.00 g), and the mixture was stirred at room temperature for 24 hr. The reaction mixture was adjusted to pH 3 to 4 with 1M hydrochloric acid, and the mixture was extracted with ethyl acetate. The extract was washed successively with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (ethyl acetate:hexane=30:70-100:0, volume ratio) to give the title compound (3.57 g, yield 63%) as colorless crystals. melting point 188-189° C.

Provenance & Evidence