Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1881929생성일: 2026년 10월 25일
1-Hydroxybenzotriazole → Ethyl [2-({[tert-butyl(diphenyl)silyl]oxy}acetyl)hydrazino](oxo)acetate
https://huagongshe.com/reaction/1881929
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | Ethyl 2-hydrazinyl-2-oxoacetate | HCID 2786935 | — |
| 반응물 | 2-((tert-Butyldiphenylsilyl)oxy)acetic acid | HCID 11141564 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Ethyl [2-({[tert-butyl(diphenyl)silyl]oxy}acetyl)hydrazino](oxo)acetate | HCID 59331270 | 30.3% |
반응 단계
To a solution of ethyl hydrazino(oxo)acetate (3.58 g) in acetonitrile (100 mL) were successively added triethylamine (6.86 mL), {[tert-butyl(diphenyl)silyl]oxy}acetic acid (7.74 g), N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride (5.20 g) and 1-hydroxybenzotriazole (415 mg) under ice-cooling. The reaction mixture was warmed to room temperature and stirred overnight. The reaction mixture was diluted with ethyl acetate, washed with water and saturated aqueous sodium hydrogen carbonate. The ethyl acetate layer was dried (MgSO4) and concentrated. The residue was subjected to silica gel column chromatography, and the title compound (3.20 g, yield 30%) was obtained as a colorless amorphous solid from a fraction eluted with ethyl acetate-hexane (1:1, volume ratio).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08318746B2 |
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| 출처 데이터셋 | uspto-grants-2012_11 |
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| ORD ID | ord-f81bd77762e7496785d175a139d9a3ec |
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| 출처 메모 | uspto-grants-2012_11 |
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