[5-({[Tert-butyl(diphenyl)silyl]oxy}methyl)-1,3,4-thiadiazol-2-yl]methanol → 5-({[Tert-butyl(diphenyl)silyl]oxy}methyl)-1,3,4-thiadiazole-2-carbaldehyde

Participants

Reaction Steps

To a solution of [5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-1,3,4-thiadiazol-2-yl]methanol (242 mg) in toluene (2 mL) was added manganese dioxide (693 mg), and the mixture was stirred at room temperature for 1 hr. The reaction mixture was filtered through celite, and the filtrate was concentrated to give the title compound (171 mg) as a colorless amorphous solid.

Provenance & Evidence