Hydrochloric Acid → HCID 59331329, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 2-[4-(methylsulfonyl)phenyl]-3-(tetrahydrofuran-2-yl)propanoate (1.94 g) in methanol (25 mL) was added 2M aqueous sodium hydroxide solution (6.21 mL), and the mixture was stirred at 50° C. for 16 hr. The reaction mixture was acidified with 6M hydrochloric acid, and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (1.69 g, 91%) as colorless crystals.

Provenance & Evidence