Sodium Bicarbonate → HCID 59331266, compound

Participants

Reaction Steps

To a solution of tert-butyl 2-{1-[4-(cyclopropylsulfonyl)phenyl]-2-(tetrahydro-2H-pyran-4-yl)ethyl}-5-(5-formylpyridin-2-yl)-1H-pyrrole-1-carboxylate (3 g) in ethanol (10 mL) was added sodium borohydride (221 mg), and the mixture was stirred at room temperature for 10 min. Saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, dried (MgSO4) and concentrated. The residue was subjected to silica gel column chromatography, and the title compound (3 g, yield 100%) was obtained as a pale-yellow amorphous solid from a fraction eluted with hexane-ethyl acetate (1:1, volume ratio). MS: 567 (MH+).

Provenance & Evidence