Ammonium Acetate → HCID 59331510, compound

Participants

Reaction Steps

To a solution (10 mL) of 3-cyclopentyl-2-[4-(methylsulfonyl)phenyl]-N-(2-oxo-2-pyridin-2-ylethyl)propanamide (330 mg) in acetic acid was added ammonium acetate (310 mg), and the mixture was stirred with heating under reflux for 4 hr. After cooling to room temperature, the reaction mixture was concentrated, the residue was diluted with ethyl acetate, and the mixture was washed with saturated aqueous sodium hydrogen carbonate. The ethyl acetate layer was concentrated, and the residue was subjected to preparative high performance liquid chromatography to give the title compound (80 mg, yield 25%) as colorless amorphous crystals. MS: 396 (MH+).

Provenance & Evidence