Sodium Thiosulfate → HCID 178504726, compound

Participants

Reaction Conditions

Reaction Steps

To a solution (12 mL) of (2-{2-cyclopentyl-1-[4-(methylsulfonyl)phenyl]ethyl}-1H-imidazol-5-yl)(cyclopropyl)methanone in 1,2-dichloroethane was added N-chlorosuccinimide (0.091 g) and the mixture was stirred at 100° C. for 6 hr. To the reaction mixture were successively added saturated aqueous sodium hydrogen carbonate solution and 1 mol/L aqueous sodium thiosulfate solution, and the mixture was extracted with ethyl acetate. The extract was washed successively with water and saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was successively purified by silica gel column chromatography (ethyl acetate:hexane=10:90-50:50, volume ratio) and thin layer chromatography (ethyl acetate:hexane=50:50), and recrystallized from diisopropyl ether-hexane to give the title compound (0.016 g, yield 9%) as colorless crystals. melting point 95-97° C.

Provenance & Evidence