Xenon difluoride → HCID 178516169, compound

Participants

Reaction Steps

To a solution (16 mL) of (3R)-3-{2-[5-(cyclobutylcarbonyl)-1H-imidazol-2-yl]-2-[4-(cyclopropylsulfonyl)phenyl]ethyl}cyclopentanone (0.720 g) in acetonitrile was added xenon difluoride (0.552 g), and the mixture was heated under reflux for 4 hr. The reaction mixture was poured into ice water, and the mixture was extracted with ethyl acetate. The extract was washed successively with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=30:70-100:0, volume ratio), and recrystallized from diethyl ether-hexane to give the title compound (0.035 g, yield 5%) as colorless crystals. melting point 85-88° C.

Provenance & Evidence