Trifluoroacetic acid → 4-[1-{5-[5-(hydroxymethyl)-1,3-thiazol-2-yl]-1H-pyrrol-2-yl}-2-(tetrahydro-2H-pyran-4-yl)ethyl]benzoic acid

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Reaction Steps

To a solution of tert-butyl 4-[1-{5-[5-(hydroxymethyl)-1,3-thiazol-2-yl]-1H-pyrrol-2-yl}-2-(tetrahydro-2H-pyran-4-yl)ethyl]benzoate (200 mg) in dichloromethane (10 mL) was added trifluoroacetic acid (2 mL) under ice-cooling, and the mixture was stirred at room temperature for 3 hr. The reaction mixture was concentrated and subjected to preparative HPLC to give the title compound (60.0 mg, yield 34%) as a pale-yellow solid. MS: 413 (MH+).

Provenance & Evidence