Sodium Bicarbonate → HCID 59331315, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 4-[4-(cyclopropylsulfonyl)phenyl]-3-oxo-2-[2-oxo-2-(1,3-thiazol-2-yl)ethyl]-5-(tetrahydro-2H-pyran-4-yl)pentanoate (0.190 g) in acetic acid (5 mL) was added ammonium acetate (0.411 g) at room temperature, and the mixture was stirred at 100° C. for 15 hr. To the reaction mixture was added saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The extract was washed successively with water and saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=30:70-70:30, volume ratio) to give the title compound (0.126 g, yield 68%) as a colorless amorphous solid. MS: 515 (MH+). melting point 178-179° C.

Provenance & Evidence