Tetrahydrofuran → HCID 59331231, compound

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A mixture of ethyl (2E)-3-[2-(5-{1-[4-(cyclopropylsulfonyl)phenyl]-2-(tetrahydro-2H-pyran-4-yl)ethyl}-1H-pyrrol-2-yl)-1,3-thiazol-5-yl]propenoate (0.78 g), 10% palladium carbon (containing 50% water, 0.15 g), tetrahydrofuran (10 mL) and ethanol (5 mL) was stirred under hydrogen atmosphere at room temperature for 2 days. The insoluble material was filtered off, and the filtrate was concentrated. The obtained residue was subjected to silica gel column chromatography, and the title compound (0.58 g, yield 79%) was obtained as a yellow amorphous solid from a fraction eluted with ethyl acetate-hexane (2:1, volume ratio). MS: 543 (MH+).

Provenance & Evidence