Xenon difluoride → HCID 178527329, compound

Participants

Reaction Steps

To a solution of 2-(2-{1-[4-(cyclopropylsulfonyl)phenyl]-2-(tetrahydro-2H-pyran-4-yl)ethyl}-1H-imidazol-5-yl)pyridine (0.750 g) in acetonitrile (20 mL) was added xenon difluoride (434 mg), and the mixture was stirred at room temperature for 30 min, and at 0° C. for 63 hr. To the reaction mixture was added saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The extract was washed successively with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=10:90-100:0, volume ratio) and preparative thin layer chromatography to give the title compound (0.008 g, yield 1%) as a yellow oil. MS: 456 (MH+).

Provenance & Evidence