Hydrochloric Acid → HCID 178503158, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-[3-chloro-4-(methylsulfanyl)phenyl]-1-(4-chloro-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl)-2-(tetrahydro-2H-pyran-4-yl)ethanol (1.47 g) in ethanol (40 mL) was added 3M hydrochloric acid (40 mL), and the mixture was stirred at 80° C. for 1.5 hr. To the reaction mixture was added saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The extract was washed successively with water and saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=30:70-80:20, volume ratio) to give the title compound (1.10 g, yield 100%) as a colorless amorphous solid. MS: 446 (MH+).

Provenance & Evidence