Water → HCID 59331302, compound

Participants

Reaction Steps

To a mixture of 1-[6-(5-{1-[5-(methylsulfanyl)pyridin-2-yl]-2-(tetrahydro-2H-pyran-4-yl)ethyl}-1H-pyrrol-2-yl)pyridin-3-yl]ethanol (76.1 mg), tetrahydrofuran (1 mL), water (1 mL) and methanol (1 mL) was added Oxone (registered trademark) (133 mg), and the mixture was stirred at room temperature for 4 hr. The reaction mixture was diluted with ethyl acetate, and washed with saturated aqueous sodium hydrogen carbonate solution. The ethyl acetate layer was dried (MgSO4) and concentrated. The residue was subjected to silica gel column chromatography, and the title compound (40.3 mg, yield 49%) was obtained as a white amorphous solid from a fraction eluted with ethyl acetate-hexane (19:1, volume ratio). MS: 456 (MH+).

Provenance & Evidence