Acetic Acid → HCID 59331506, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (5E)-5-[4-(cyclopropylsulfonyl)phenyl]-1-[5-(1,2-dihydroxy-2-methylpropyl)pyridin-2-yl]-6-(tetrahydro-2H-pyran-4-yl)hex-5-ene-1,4-dione (4.79 g), ammonium acetate (3.40 g) and acetic acid (15 mL) was stirred at 90° C. for 2 hr. Water was added to the reaction mixture, and the mixture was neutralized with 8N aqueous sodium hydroxide solution. The precipitated solid was collected by filtration, washed with water, and dried. The obtained solid was dissolved in tetrahydrofuran, and the solution was treated with activated carbon and concentrated. Cold ethyl acetate was added to the obtained residue to allow crystallization. The crystals were collected by filtration, washed with cold ethyl acetate and dried to give the title compound (3.38 g, yield 73%) as pale-yellow crystals. melting point 196-197° C. MS: 523 (MH+).

Provenance & Evidence