Methanol → 2-[6-(5-{1-[4-(cyclopropylsulfonyl)phenyl]-2-(tetrahydro-2H-pyran-4-yl)ethyl}-1H-pyrrol-2-yl)pyridin-3-yl]ethanol

Participants

Reaction Steps

To a mixture of methyl [6-(5-{1-[4-(cyclopropylsulfonyl)phenyl]-2-(tetrahydro-2H-pyran-4-yl)ethyl}-1H-pyrrol-2-yl)pyridin-3-yl]acetate (400 mg), tetrahydrofuran (10 mL) and methanol (2 mL) was added lithium borohydride (85 mg) at room temperature, and the mixture was stirred at room temperature for 3 hr. To the reaction mixture was added water and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, dried (MgSO4) and concentrated. The residue was subjected to silica gel column chromatography to give the title compound as a crude product from a fraction eluted with hexane-ethyl acetate-methanol (1:4:0-0:95:5, volume ratio), the crude product was subjected to preparative HPLC to give the title compound (150 mg, yield 39%) as a pale-yellow amorphous solid. MS: 481 (MH+).

Provenance & Evidence