2-Thiazolamine, 4-(trifluoromethyl)- → HCID 46834136, compound

Participants

Reaction Steps

The title compound was prepared according to the general procedure (Method B) by coupling Intermediate 8 (300 mg, 0.710 mmol) with 4-(trifluoromethyl)-1,3-thiazol-2-amine (128 mg, 0.781 mmol) in the presence of EDCI hydrochloride (272 mg, 1.42 mmol), DMAP (80 mg, 0.710 mmol) in a mixture of THF and DMF (1:1, 6 mL) to give 35 mg of the product as an off-white solid; 1H NMR (300 MHz, CDCl3) δ 0.86 (d, J=6.6 Hz, 6H), 1.56-1.65 (m, 2H), 1.77-1.86 (m, 1H), 3.95 (t, J=6.3 Hz, 2H), 7.20 (t, J=74.4 Hz, 1H), 7.22-7.30 (m, 2H), 7.46 (s, 1H), 7.57-7.64 (m, 2H), 7.76 (d, J=15.9 Hz, 1H), 8.05-8.12 (m, 2H), 13.03 (br s, 1H); APCI-MS (m/z) 573.23 (MH)+.

Provenance & Evidence