HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitro-3-phenyl-L-alanine → N-(2,6-Dichlorobenzoyl)-4-nitro-L-phenylalanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitro-3-phenyl-L-alanine | HCID 13706 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2,6-Dichlorobenzoyl chloride | HCID 78392 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | N-(2,6-Dichlorobenzoyl)-4-nitro-L-phenylalanine | HCID 58018322 | — |
Reaction Steps
Concretely, 4-nitro-L-phenylalanine and 2,6-dichlorobenzoylchloride are condensed in a mixed solvent of a sodium hydroxide aqueous solution and acetone with keeping the reaction temperature at 5 to 15° C., and then crystallization is conducted to obtain a corresponding condensed substance, Nα-(2,6-dichlorobenzoyl)-4-nitro-L-phenylalanine almost quantitatively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318975B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-7729fd84b55240708f87f0ec4ff3706d |
| Source note | uspto-grants-2012_11 |