Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 16124640 | HCID 16124640 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | HCID 16123108 | HCID 16123108 | 42% |
Reaction Steps
The title compound was synthesized by mixing Compound 4 (25 mg, 0.10 mmol, benzenethiol (21 μl, 0.20 mmol), caesium carbonate (33 mg, 0.10 mmol) and [1,1′-Bis(diphenylphosphino)-ferrocene]dichloropalladium(II) (7 mg, 0.01 mmol) in DMF and heating at 170° C. for 20 minutes in a microwave reactor. The product was purified by HPLC (Yield=42%). 1H NMR (400 MHz, CH3OD) δ 8.97 (d, J=7.84 1H) 8.41 (d, J=5.56 Hz 1H) 7.55 (m, 3H) 7.50 (t, 1H) 7.40 (q, 1H) 7.36 (d, J=8.84 Hz 2H) 7.12 (d, J=7.36 Hz 1H) 2.11 (s, 3H). [M+H] calc'd for C19H15N3OS 334; found, 334.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08318939B2 |
|---|
| Source dataset | uspto-grants-2012_11 |
|---|
| ORD ID | ord-9c59f7fe6c834c30971fa20a9304cfb6 |
|---|
| Source note | uspto-grants-2012_11 |
|---|
