Hydrochloric Acid → 5-[3-(Ethylsulfonyl)phenyl]-3-methyl-9H-pyrido[2,3-b]indole-7-carboxamide

Participants

Reaction Steps

Compound 126 (30 mg, 0.08 mmol) stirred in dioxane (2 mL) at r.t. A solution of potassium hydroxide (25 mg, 0.44 mmol) in 30% H2O2 solution (1 mL) was added, and the reaction stirred for 18 h. The solution was neutralized with 1N HCl and concentrated in vacuo. Purification by silica gel chromatography (5 to 8% MeOH/CH2Cl2 gave 14.8 mg (47%) of the title compound as a white solid. 1H NMR (400 MHz, CD3OD) δ 8.28 (s, 1H), 8.22 (s, 1H), 8.12 (s, 1H), 8.10 (d, 1H, J=7.6 Hz), 8.02 (d, 1H, J=7.6 Hz), 7.88 (t, 1H, J=7.6 Hz), 7.68 (s, 1H), 7.62 (s, 1H), 3.34 (q, 2H, J=7.2 Hz), 2.31 (s, 3H), 1.29 (t, 3H, J=7.2 Hz). MS (ES) [m+H] calc'd for C21H19N3O3S, 394; found 394.

Provenance & Evidence