9-(3-Ethanesulfonyl-phenyl)-5H-pyrazino[2,3-b]indole → 5-(3-Ethanesulfonyl-phenyl)-3-methyl-9H-pyrido[2,3-b]indole-7-carboxylic acid methyl ester

HRID 1882237Notes

Reaction equation

HRID 1882237 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([C:9]3[CH:17]=[C:16]([CH3:18])[CH:15]=[N:14][C:10]=3[NH:11]2)=[C:7](I)[CH:6]=1)=[O:4].[CH2:20]([S:22]([C:25]1[CH:26]=[C:27](C2C3C4N=CC=NC=4NC=3C=CC=2)[CH:28]=[CH:29][CH:30]=1)(=[O:24])=[O:23])[CH3:21]>>[CH3:1][O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([C:9]3[CH:17]=[C:16]([CH3:18])[CH:15]=[N:14][C:10]=3[NH:11]2)=[C:7]([C:27]2[CH:28]=[CH:29][CH:30]=[C:25]([S:22]([CH2:20][CH3:21])(=[O:23])=[O:24])[CH:26]=2)[CH:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 161236649-(3-Ethanesulfonyl-phenyl)-5H-pyrazino[2,3-b]indoleHCID 593787625-Iodo-3-methyl-9H-pyrido[2,3-b]indole-7-carboxylic acid methyl ester

Product 1

HCID 588801605-(3-Ethanesulfonyl-phenyl)-3-methyl-9H-pyrido[2,3-b]indole-7-carboxylic acid methyl esterYield 65%

Procedure

The title compound was prepared in 65% yield from Compound 131 according to the procedure outlined in the preparation of Compound 81. MS (ES) [m+H] calc'd for C22H20N2O4S, 409; found 409.

Sources & evidence

ORD record
ord-85cdac58d8dd4e3288219f8bf16daf40
Source dataset
uspto-grants-2012_11
Patent number
US08318939B2

Reaction notes

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