HCID 58880063, compound → HCID 58880131, compound

HRID 1882273Notes

Reaction equation

HRID 1882273 reaction equation
C(S(C1C=C(C2C=CC(O)=C3C=2C2C=C(C)C=NC=2N3)C=CC=1)(=O)=O)C.[CH2:27]([S:29]([C:32]1[CH:33]=[C:34]([C:38]2[CH:46]=[CH:45][C:44]([O:47][CH2:48][C@@H:49]([OH:52])[CH2:50][OH:51])=[C:43]3[C:39]=2[C:40]2[CH:56]=[C:55]([CH3:57])[CH:54]=[N:53][C:41]=2[NH:42]3)[CH:35]=[CH:36][CH:37]=1)(=[O:31])=[O:30])[CH3:28]>>[CH2:27]([S:29]([C:32]1[CH:33]=[C:34]([C:38]2[CH:46]=[CH:45][C:44]([O:47][CH2:48][C@H:49]([OH:52])[CH2:50][OH:51])=[C:43]3[C:39]=2[C:40]2[CH:56]=[C:55]([CH3:57])[CH:54]=[N:53][C:41]=2[NH:42]3)[CH:35]=[CH:36][CH:37]=1)(=[O:31])=[O:30])[CH3:28]

Participants

3

Reactant 2

HCID 58880063HCID 58880063, compoundHCID 588800815-(3-(ethylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-ol

Product 1

HCID 58880131HCID 58880131, compound

Procedure

The title compound was prepared from Compound 157 using an analogous procedure to the procedure described for the preparation of Compound 230. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (t, J=7.33 Hz, 3H) 2.27 (s, 3H) 3.41 (q, J=7.41 Hz, 2H) 3.60 (t, J=5.81 Hz, 2H) 3.96 (m, 1H) 4.11 (dd, J=9.60, 6.06 Hz, 1H) 4.27 (dd, J=9.60, 4.29 Hz, 1H) 4.73 (t, J=5.68 Hz, 1H) 4.99 (d, J=5.31 Hz, 1H) 7.07-7.15 (m, 2H) 7.57 (d, J=1.77 Hz, 1H) 7.85 (t, J=7.71 Hz, 1H) 7.97 (t, J=1.64 Hz, 1H) 7.99 (m, 1H) 8.09 (t, J=1.64 Hz, 1H) 8.28 (d, J=2.02 Hz, 1H) 11.93 (s, 1H); [M+H] calc'd for C23H25N2O5S, 441.1; found, 441.4.

Sources & evidence

ORD record
ord-2fac2cd4e423407098bb7fd5d671c6f1
Source dataset
uspto-grants-2012_11
Patent number
US08318939B2

Reaction notes

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