Acetaminophen → Ethyl 2-(4-acetamidophenoxy)acetate

Participants

Reaction Steps

To a mixture of Paracetamol (300 grams, 1.984 mol), anhydrous K2CO3 (1.80 Kg, 7.814 mmol) in anhydrous acetone (3 liters) was added ethyl bromo acetate (452 grams, 2.7 mol) and refluxed for 16 hours. Acetone was distilled and water (5 liter) was added. Crude 59 was filtered, dried, and recrystallized from a mixture of toluene:Hexane (1:5) to give pure 59 (377 grams, 80%) as a white shining powder. The melting point was found to be 104.2-106.2° C.

Provenance & Evidence