2-(4-Acetylamino-phenoxy)-propionic acid methyl ester → 2-(4-Aminophenoxy)propanoic acid

Participants

Reaction Conditions

Reaction Steps

To a mixture 2-(4-acetylamino-phenoxy)-propionic acid methyl ester 62 (320 grams, 1.35 mol) in concentrated hydrochloric acid (8 liters) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 63 (240 grams, 81.7%) as a brown powder. The melting point was found to be 175-180° C.

Provenance & Evidence