HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1882313Generated: October 25, 2026
Hydrochloric Acid → 6-(4-Amino-phenoxy)hexanoic acid hydrochloride
https://huagongshe.com/reaction/1882313
Participants
| Role | Name | HCID | Charge |
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| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-(4-Acetylaminophenoxy)-hexanoic acid methyl ester | HCID 49764491 | — |
| Product | 6-(4-Amino-phenoxy)hexanoic acid hydrochloride | HCID 66811347 | 55.6% |
Reaction Steps
To a mixture of 6-(4-Acetylamino-phenoxy)-hexanoic acid methyl ester 65 (290 grams, 1.04 moles), in concentrated hydrochloric acid (7.12 Liter) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried give pure 66 (150 grams, 55.6%) as a brown powder. The melting point was found to be 155-160° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08318973B2 |
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| Source dataset | uspto-grants-2012_11 |
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| ORD ID | ord-51cc37b37f844c449f5ca773cf4c60ec |
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| Source note | uspto-grants-2012_11 |
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