Methyl 2-(2-(4-nitrophenoxy)ethoxy)acetate → HCID 59253936, compound

Participants

Reaction Steps

[2-(4-Nitrophenoxy)-ethoxy]acetic acid methyl ester 74 (1 grams, 3.9 mmol) was dissolved in anhydrous ethyl acetate (20 mL), palladium carbon (10%, 0.1 gram) added and the mixture stirred under an atmosphere of H using balloon for 30 minutes. The catalyst was filtered, the filtrate concentrate hexane (3 mL) added, filtered solid to give 75 (625 mg, 70.9%) as a light brown powder. The melting point was found to be 51-52.5° C. The structure was confirmed with IR and NMR. IHNMR (CDCl3) 3.04 (bs, 2H, NH2), 3.72 (s, 3H, ester), 3.88 (t, 2H, OCH2), 4.08 (t, 2H, OCH2), 4.20 (s, 2H, OCH2), 6.58 (d, 2H, Ar), 6.70 (d, 2H, Ar).

Provenance & Evidence