HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1882321Generated: October 30, 2026
Hydrochloric Acid → 4-(Carboxymethoxy)benzoic acid
https://huagongshe.com/reaction/1882321
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | methyl 4-(2-methoxy-2-oxoethoxy)benzoate | HCID 887006 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(Carboxymethoxy)benzoic acid | HCID 88024 | 91.4% |
Reaction Steps
4-Methoxycarbonylmethoxy-benzoic acid methyl ester 1 (50 grams, 223 mmol) was added to a solution of 2.5 M sodium hydroxide (250 mL) and heated to 80° C. for 5 hours. The reaction mixture was dilated with water (100 mL) and pH adjusted to 1 with concentrated HCl. Crude 76 was filtered, dried and given hot ethyl acetate slurry to give 76 (40 grams, 91.4%) as a white powder. M.p: >280° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08318973B2 |
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| Source dataset | uspto-grants-2012_11 |
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| ORD ID | ord-96efc83c26d34e4bb2acd342ac228817 |
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| Source note | uspto-grants-2012_11 |
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