4-Nitrophenol → Methyl (4-nitrophenoxy)acetate

Participants

Reaction Steps

To a mixture of 4-Nitro phenol (100 grams, 719 mmol), anhydrous K2CO3 (400 grams, 2.894 moles) in anhydrous acetone (950 mL) was added methyl chloroacetate (114 grams, 1.050 moles) and refluxed for 12 hours. Acetone was distilled and water (1500 mL) was added. Crude 93 was filtered, dried, and recrystallized from a mixture of Ethyl acetate:Hexane (1:5) to give pure 93 (110 grams, 72.5%) as a white fluffy powder. M.p: 97-98.4° C.

Provenance & Evidence