Ethanol → HCID 67543117, compound

Participants

Reaction Steps

To methyl 2-ethyl-3-(phenylthio)acrylate (4.39 g) were added ethanol (40 mL) and then a 2N aqueous sodium hydroxide solution (20 mL), and the mixture was refluxed at room temperature for 2 hours. After the reaction mixture was cooled to room temperature, water (100 mL) was added thereto, and further tert-butyl methyl ether was added, thereby layers were separated. The aqueous layer was adjusted to pH 2 by addition of conc. hydrochloric acid, and then extracted with tert-butyl methyl ether. The organic layer was washed with a saturated aqueous sodium chloride solution, dried, and then concentrated to obtain 2-ethyl-3-(phenylthio)acrylic acid (4.07 g).

Provenance & Evidence