HCID 57919741, compound → HCID 58051136, compound

HRID 1882353Notes

Reaction equation

HRID 1882353 reaction equation
[NH2:1][C@@H:2]([CH3:16])[CH2:3][NH:4][C:5]1[S:6][C:7]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:8]([CH3:10])[N:9]=1.N[C@H](C)CNC1SC([C:27](OCC)=[O:28])=C(C)N=1>>[CH3:10][C:8]1[N:9]=[C:5]([N:4]2[CH2:3][C@@H:2]([CH3:16])[NH:1][C:27]2=[O:28])[S:6][C:7]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

3

Reactant 2

HCID 57919741HCID 57919741, compoundHCID 57919869HCID 57919869, compound

Product 1

HCID 58051136HCID 58051136, compound

Procedure

Following the procedure as described in Preparation 4, making variations as required to replace (S)-ethyl 2-(2-aminopropylamino)-4-methylthiazole-5-carboxylate with (R)-ethyl 2-(2-aminopropylamino)-4-methylthiazole-5-carboxylate, the title compound was obtained as a colorless solid (74%): MS (ES+) m/z 269.7 (M+1).

Workup

  1. customas described in Preparation 4

Sources & evidence

ORD record
ord-ea91376b64ae4968a8799eaee9d0fdc6
Source dataset
uspto-grants-2012_11
Patent number
US08318949B2

Reaction notes

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