HCID 57919741, compound → HCID 58051131, compound

HRID 1882355Notes

Reaction equation

HRID 1882355 reaction equation
N[C@@H](C)CNC1SC([C:11](OCC)=[O:12])=C(C)N=1.[NH2:17][CH2:18][C@@H:19]([NH:21][C:22]1[S:23][C:24]([C:28]([O:30][CH2:31][CH3:32])=[O:29])=[C:25]([CH3:27])[N:26]=1)[CH3:20]>>[CH3:27][C:25]1[N:26]=[C:22]([N:21]2[C@@H:19]([CH3:20])[CH2:18][NH:17][C:11]2=[O:12])[S:23][C:24]=1[C:28]([O:30][CH2:31][CH3:32])=[O:29]

Participants

3

Reactant 2

HCID 57919741HCID 57919741, compoundHCID 57919758HCID 57919758, compound

Product 1

HCID 58051131HCID 58051131, compound

Procedure

Following the procedure as described in Preparation 4, making variations as required to replace (S)-ethyl 2-(2-aminopropylamino)-4-methylthiazole-5-carboxylate with (S)-ethyl 2-(1-aminopropan-2-ylamino)-4-methylthiazole-5-carboxylate, the title compound was obtained as a colorless solid (52%): MS (ES+) m/z 269.7 (M+1).

Workup

  1. customas described in Preparation 4

Sources & evidence

ORD record
ord-69874a02d53f4fafaf2248c134a7aff9
Source dataset
uspto-grants-2012_11
Patent number
US08318949B2

Reaction notes

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