HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-2-methylpropane → Ethyl 2-(3-isobutyl-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-2-methylpropane | HCID 6555 | — |
| Reactant | 2-(Bromomethyl)-1,1-difluorocyclopropane | HCID 2761402 | — |
| Reactant | Ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate | HCID 57919776 | — |
| Product | Ethyl 2-(3-isobutyl-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate | HCID 57919846 | 98% |
Reaction Steps
Following the procedure as described in Preparation 13, making variations to replace bromomethyl-2,2-difluorocyclopropane with 1-bromo-2-methylpropane to react with ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate, the title compound was obtained in 98% yield: MS (ES+) m/z 311.8 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318949B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-845cb596385140d4aac2a91050166f3e |
| Source note | uspto-grants-2012_11 |