2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylic acid → HCID 57919979, compound

HRID 1882413Notes

Reaction equation

HRID 1882413 reaction equation
FC1C=CC(C[N:7]2C(=O)N(C3SC(C(O)=O)=C(C)N=3)C=N2)=CC=1.[F:24][C:25]1[CH:26]=[C:27]([CH:44]=[C:45]([F:47])[CH:46]=1)[CH2:28][N:29]1[CH2:33][CH2:32][N:31]([C:34]2[S:35][C:36]([C:40](O)=[O:41])=[C:37]([CH3:39])[N:38]=2)[C:30]1=[O:43]>>[F:47][C:45]1[CH:44]=[C:27]([CH:26]=[C:25]([F:24])[CH:46]=1)[CH2:28][N:29]1[CH2:33][CH2:32][N:31]([C:34]2[S:35][C:36]([C:40]([NH2:7])=[O:41])=[C:37]([CH3:39])[N:38]=2)[C:30]1=[O:43]

Participants

3

Reactant 2

HCID 579198022-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylic acidHCID 66661474HCID 66661474, compound

Product 1

HCID 57919979HCID 57919979, compound

Procedure

Following the procedure as described in EXAMPLE 1, making variations as required to replace 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylic acid with 2-(3-(3,5-difluorobenzyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid, the title compound was obtained as a colorless solid: mp>200° C.; 1H NMR (300 MHz, DMSO-d6) δ 7.32 (br s, 2H), 7.21-7.04 (m, 3H), 4.47 (s, 2H), 4.05-4.00 (m, 2H), 3.54-3.48 (m, 2H), 2.47 (s, 3H); MS (ES+) m/z 352.8 (M+1).

Sources & evidence

ORD record
ord-56cf0f0e5e9a461fa6d42b7ce834da94
Source dataset
uspto-grants-2012_11
Patent number
US08318949B2

Reaction notes

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