2-({4-[2-(Cyclobutylmethoxy)ethyl]phenoxy}methyl)oxirane → 6-[4-[3-[3-(4-(2-Cyclobutylmethoxy-ethyl)phenoxy)-2-hydroxypropylamino]propoxy]-3-methyl-phenyl]-4,5-dihydro-3(2H)-pyridazinone

HRID 188243Notes

Reaction equation

HRID 188243 reaction equation
[CH:1]1([CH2:5][O:6][CH2:7][CH2:8][c:9]2[cH:10][cH:11][c:12]([O:13][CH2:14][CH:15]3[CH2:16][O:17]3)[cH:18][cH:19]2)[CH2:2][CH2:3][CH2:4]1.[NH2:20][CH2:21][CH2:22][CH2:23][O:24][c:25]1[c:26]([CH3:38])[cH:27][c:28]([C:31]2=[N:36][NH:35][C:34](=[O:37])[CH2:33][CH2:32]2)[cH:29][cH:30]1>>[CH:1]1([CH2:5][O:6][CH2:7][CH2:8][c:9]2[cH:10][cH:11][c:12]([O:13][CH2:14][CH:15]([CH2:16][NH:20][CH2:21][CH2:22][CH2:23][O:24][c:25]3[c:26]([CH3:38])[cH:27][c:28]([C:31]4=[N:36][NH:35][C:34](=[O:37])[CH2:33][CH2:32]4)[cH:29][cH:30]3)[OH:17])[cH:18][cH:19]2)[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 151078052-({4-[2-(Cyclobutylmethoxy)ethyl]phenoxy}methyl)oxiraneHCID 151078206-[4-(3-aminopropoxy)-3-methyl-phenyl]-4,5-dihydro-3(2H)-pyridazinone

Product 1

HCID 148844186-[4-[3-[3-(4-(2-Cyclobutylmethoxy-ethyl)phenoxy)-2-hydroxypropylamino]propoxy]-3-methyl-phenyl]-4,5-dihydro-3(2H)-pyridazinone

Sources & evidence

ORD record
ord-75476f3f82c24cd7b94584212d6e6c11
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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