3-Pyridinemethanamine → (R)-2-(3-(4-fluorobenzyl)-4-methyl-2-oxoimidazolidin-1-yl)-4-methyl-N-((5-methylisoxazol-3-yl)methyl)thiazole-5-carboxamide

Participants

Reaction Steps

Following the procedure as described in Example 2, making variations as required to replace pyridin-3-ylmethanamine with (5-methylisoxazol-3-yl)methanamine and replace (S)-2-(3-(4-fluorobenzyl)-4-methyl-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid with (R)-2-(3-(4-fluorobenzyl)-4-methyl-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid the title compound was obtained as a white solid: mp 139-140° C. (diethyl ether); 1H NMR (300 MHz, DMSO-d6) δ 8.51 (t, J=5.8 Hz, 1H), 7.40-7.35 (m, 2H), 7.21-7.15 (m, 2H), 6.14 (d, J=0.4 Hz, 1H), 4.60 (d, J=15.6 Hz, 1H), 4.37-4.16 (m, 4H), 3.78-3.71 (m, 1H), 3.55 (dd, J=10.2, 6.8 Hz, 1H), 2.47 (s, 3H), 2.37 (s, 3H), 1.22 (d, J=6.2 Hz, 3H); MS (ES+) m/z 443.9 (M+1).

Provenance & Evidence