HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[1-(2-pyridinyl)-4-piperidinyl]-1H-imidazole-1-carboxamide → 4-[(Imidazole-1-carbonyl)-amino]-piperidine-1-carboxylic acid (3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[1-(2-pyridinyl)-4-piperidinyl]-1H-imidazole-1-carboxamide | HCID 21978278 | — |
| Reactant | 4-Amino-piperidine-1-carboxylic acid (3,4,5,6-tetrahydro-2H-[1,2']bipy ridinyl-4-yl)-amide dihydrochloride | HCID 66630092 | — |
| Product | 4-[(Imidazole-1-carbonyl)-amino]-piperidine-1-carboxylic acid (3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-amide | HCID 66630314 | — |
Reaction Steps
The title product is prepared analogously to imidazole-1-carboxylic acid (3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-amide (Intermediate A1) by replacing 3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-ylamine dihydrochloride with 4-amino-piperidine-1-carboxylic acid (3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-amide dihydrochloride (Intermediate H2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318750B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-e13076ada05241cab0b65b2c44261e3c |
| Source note | uspto-grants-2012_11 |