3-[3-((R)-1-benzyl-pyrrolidin-3-yl)-ureido]-benzenesulfonamide → 3-((R)-3-pyrrolidin-3-ylureido)-benzenesulfonamide

Participants

Reaction Steps

A solution of 3-[3-((R)-1-benzyl-pyrrolidin-3-yl)-ureido]-benzenesulfonamide (25 g, 0.067 mol) in ethanol (250 mL) is purged with nitrogen, and palladium hydroxide (2.5 g, 20% w/w) is added. The suspension is purged with hydrogen and stirred under a positive pressure of hydrogen for 24 hours. Filtration though Celite® (filter material) and removal of solvent under reduced pressure gives the product as a colourless waxy solid.

Provenance & Evidence