Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1882539Generated: October 30, 2026

3-(tert-Butoxy)propionic acid → 3-tert-Butoxy-N-[(1S,2R,3S,4R)-4-(2,6-dichloro-purin-9-yl)-2,3-dihydroxy-cyclopentyl]-propionamide

https://huagongshe.com/reaction/1882539

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(tert-Butoxy)propionic acidHCID 2760949—
Reactant(R)-2-benzyloxy-N-[(1S,2R,3S,4R)-4-(2,6-dichloro-purin-9-yl)-2,3-dihydroxy-cyclopentyl]-propionamideHCID 86647544—
Product3-tert-Butoxy-N-[(1S,2R,3S,4R)-4-(2,6-dichloro-purin-9-yl)-2,3-dihydroxy-cyclopentyl]-propionamideHCID 86647543—

Reaction Steps

The title compound is prepared as described for (R)-2-benzyloxy-N-[(1S,2R,3S,4R)-4-(2,6-dichloro-purin-9-yl)-2,3-dihydroxy-cyclopentyl]-propionamide (Example 181, Step 1), by replacing (R)-2-benzyloxy-propionic acid with 3-tert-butoxypropionic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08318750B2
Source datasetuspto-grants-2012_11
ORD IDord-355bfaadc6574ed9aed3989151b30e6f
Source noteuspto-grants-2012_11