HRID1882544

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID447213

L-phenylalaninol

C9H13NO

结构：CC(=O)OCC(=O)N[C@H]1C[C@@H](n2cnc3c(N[C@H](CO)Cc4ccccc4)nc(Cl)nc32)[C@H](O)[C@@H]1O

HCID86632439

未命名化合物

PRODUCTS

生成物

结构：CC(=O)OCC(=O)N[C@H]1C[C@@H](n2cnc3c(N[C@H](CO)Cc4ccc(O)cc4)nc(Cl)nc32)[C@H](O)[C@@H]1O

HCID86647546

未命名化合物

PROCEDURE

实验过程

The title compound is prepared analogously to acetic acid {(1S,2R,3S,4R)-4-[2-chloro-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentylcarbamoyl}-methyl ester (intermediate ZM), by substituting 4-((S)-2-amino-3-hydroxy-propyl)-phenol for (S)-2-amino-3-phenyl-propan-1-ol.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ba0977f4bb4445efa8a82bb9cd68ed6e
来源数据集: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08318750B2
来源说明: uspto-grants-2012_11

反应 SMILES

[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@@H:11]2[CH2:15][C@H:14]([NH:16][C:17]([CH2:19][O:20][C:21](=[O:23])[CH3:22])=[O:18])[C@@H:13]([OH:24])[C@H:12]2[OH:25])=[C:4]([NH:26][C@H:27]([CH2:35][OH:36])[CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[N:3]=1.N[C@@H](CC1C=CC=CC=1)C[OH:40]>>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@@H:11]2[CH2:15][C@H:14]([NH:16][C:17]([CH2:19][O:20][C:21](=[O:23])[CH3:22])=[O:18])[C@@H:13]([OH:24])[C@H:12]2[OH:25])=[C:4]([NH:26][C@H:27]([CH2:35][OH:36])[CH2:28][C:29]2[CH:34]=[CH:33][C:32]([OH:40])=[CH:31][CH:30]=2)[N:3]=1