Isonicotinoyl chloride hydrochloride → Hydrochloric Acid

참여 물질

역할	이름	HCID	투입량
반응물	Isonicotinoyl chloride hydrochloride	HCID 12262826	—
반응물	N-((1S,2R,3S,4R)-4-{2-((R)-3-Amino-pyrrolidin-1-yl)-6-[2,2-bis-(4-hydroxy-phenyl)-ethylamino]-purin-9-yl}-2,3-dihydroxy-cyclopentyl)-propionamide	HCID 66630815	—
용매	Tetrahydrofuran	HCID 8028	—
용매	N-methyl-2-pyrrolidone	HCID 13387	—
생성물	Hydrochloric Acid	HCID 313	—
생성물	N-{(R)-1-[6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-((1R,2S,3R,4S)-2,3-dihydroxy-4-propionylamino-cyclopentyl)-9H-purin-2-yl]-pyrrolidin-3-yl}-isonicotinamide hydrochloride	HCID 66629861	—

반응 단계

A mixture comprising N-((1S,2R,3S,4R)-4-{2-((R)-3-amino-pyrrolidin-1-yl)-6-[2,2-bis-(4-hydroxy-phenyl)-ethylamino]-purin-9-yl}-2,3-dihydroxy-cyclopentyl)-propionamide (Example 22 step 4) (20 mg, 33 μmol) in THF (0.5 ml) and NMP (0.5 ml) is treated with TEA (13 mg, 0.13 mmol) followed by isonicotinoyl chloride hydrochloride (16 mg, 83 μmol). After stirring at room temperature for 2 hours, the solvent is removed in vacuo and purification by C-18 reverse phase column chromatography eluting with acetonitrile:water:HCl (0.1%) (gradient of 0 to 100% acetonitrile) yields the title compound. (MH+ 708.4)

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08318750B2
출처 데이터셋	uspto-grants-2012_11
ORD ID	ord-1a44f918f635453098f935faaafa6e0a
출처 메모	uspto-grants-2012_11