1-Methyl-1h-1,2,3-benzotriazole-5-carbonyl chloride → HCID 66630470, 화합물

HRID 1882595노트

반응식

HRID 1882595 반응식
Cl.[OH:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:47]2[CH:52]=[CH:51][C:50]([OH:53])=[CH:49][CH:48]=2)[CH2:10][NH:11][C:12]2[N:20]=[C:19]([N:21]3[CH2:25][CH2:24][C@@H:23]([NH:26][C:27](=[O:34])[C:28]4[CH:33]=[CH:32][N:31]=[CH:30][CH:29]=4)[CH2:22]3)[N:18]=[C:17]3[C:13]=2[N:14]=[CH:15][N:16]3[C@@H:35]2[CH2:39][C@H:38]([NH:40][C:41](=[O:44])[CH2:42][CH3:43])[C@@H:37]([OH:45])[C@H:36]2[OH:46])=[CH:5][CH:4]=1.[CH3:54][N:55]1[C:59]2C=CC(C([Cl:66])=O)=CC=2N=[N:56]1>>[ClH:66].[OH:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:47]2[CH:48]=[CH:49][C:50]([OH:53])=[CH:51][CH:52]=2)[CH2:10][NH:11][C:12]2[N:20]=[C:19]([N:21]3[CH2:25][CH2:24][C@@H:23]([NH:26][C:27]([C:28]4[CH:33]=[CH:32][C:54]5[N:55]([CH3:59])[N:56]=[N:31][C:30]=5[CH:29]=4)=[O:34])[CH2:22]3)[N:18]=[C:17]3[C:13]=2[N:14]=[CH:15][N:16]3[C@@H:35]2[CH2:39][C@H:38]([NH:40][C:41](=[O:44])[CH2:42][CH3:43])[C@@H:37]([OH:45])[C@H:36]2[OH:46])=[CH:5][CH:4]=1

참가 물질

3

반응물 2

HCID 27765501-Methyl-1h-1,2,3-benzotriazole-5-carbonyl chlorideHCID 66629861N-{(R)-1-[6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-((1R,2S,3R,4S)-2,3-dihydroxy-4-propionylamino-cyclopentyl)-9H-purin-2-yl]-pyrrolidin-3-yl}-isonicotinamide hydrochloride

생성물 1

HCID 66630470HCID 66630470, 화합물

실험 절차

This compound is prepared analogously to N-{(R)-1-[6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-((1R,2S,3R,4S)-2,3-dihydroxy-4-propionylamino-cyclopentyl)-9H-purin-2-yl]-pyrrolidin-3-yl}-isonicotinamide hydrochloride (Example 158) by replacing isonicotinoyl chloride hydrochloride with 1-methyl-1H-1,2,3-benzotriazole-5-carbonyl chloride. (MH+ 762.4)

출처 및 근거

ORD 기록
ord-c5a326bb52d549e0876e2ccbc980cc8a
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318750B2

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