Phenyl pyridin-3-ylcarbamate → HCID 66630078, compound

HRID 1882622Notes

Reaction equation

HRID 1882622 reaction equation
[OH:1][C@H:2]1[C@@H:6]([OH:7])[C@H:5]([N:8]2[CH:16]=[N:15][C:14]3[C:9]2=[N:10][C:11]([N:33]2[CH2:37][CH2:36][C@@H:35]([NH:38][C:39]([NH:41][C:42]4[CH:43]=NC=CC=4)=[O:40])[CH2:34]2)=[N:12][C:13]=3[NH:17][CH2:18][C:19]([OH:32])([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:4][C@@H:3]1[NH:48][C:49](=[O:52])[CH2:50][OH:51].[C:53]1([O:59]C(=O)NC2C=NC=CC=2)[CH:58]=C[CH:56]=[CH:55][CH:54]=1>>[OH:1][C@H:2]1[C@@H:6]([OH:7])[C@H:5]([N:8]2[CH:16]=[N:15][C:14]3[C:9]2=[N:10][C:11]([N:33]2[CH2:37][CH2:36][C@@H:35]([NH:38][C:39]([NH:41][CH2:42][C:43]4[CH:56]=[CH:55][CH:54]=[C:53]([OH:59])[CH:58]=4)=[O:40])[CH2:34]2)=[N:12][C:13]=3[NH:17][CH2:18][C:19]([OH:32])([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:4][C@@H:3]1[NH:48][C:49](=[O:52])[CH2:50][OH:51]

Participants

3

Reactant 2

HCID 6935890Phenyl pyridin-3-ylcarbamateHCID 66631057HCID 66631057, compound

Product 1

HCID 66630078HCID 66630078, compound

Procedure

The title compound is prepared analogously to N-((1S,2R,3S,4R)-2,3-dihydroxy-4-{6-(2-hydroxy-2,2-diphenyl-ethylamino)-2-[(R)-3-(3-pyridin-3-yl-ureido)-pyrrolidin-1-yl]-purin-9-yl}-cyclopentyl)-2-hydroxy-acetamide (Example 192), by substituting (3-hydroxy-benzyl)-carbamic acid phenyl ester (Intermediate ZD) for pyridin-3-yl-carbamic acid phenyl ester (Intermediate ZB).

Sources & evidence

ORD record
ord-51d692ecc1c34b92aef236914245ecaa
Source dataset
uspto-grants-2012_11
Patent number
US08318750B2

Reaction notes

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